Preganglionic parasympathectomy decreases salivary SIgA secretion rates from the rat submandibular gland

被引：27

作者：

Carpenter, GH ^{[1
]}

Proctor, GB ^{[1
]}

Garrett, JR ^{[1
]}

机构：

[1] Guys Kings & St Thomas Sch Dent, Div Oral Med, Salivary Res Grp, Sch Dent, London SE1 9RT, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 160卷 / 1-2期

基金：

英国惠康基金;

关键词：

polymeric immunoglobulin receptor; saliva; secretory component; parasympathectomy; IgA; pIgR;

D O I：

10.1016/j.jneuroim.2004.10.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin A (IgA) is transported into saliva by salivary cells expressing the polymeric immunoglobulin receptor (pIgR). In rat salivary glands, autonomic nerves stimulate this process. To examine how nerves affect pIgR-mediated IgA secretion, the chorda-lingual nerve was sectioned. One week after preganglionic parasympathectomy, both the stimulated and unstimulated rates of salivary IgA secretion were reduced, despite similar glandular amounts of IgA. Biochemical analysis of cells from parasympathectomised and control glands indicated reduced membrane expression of pIgR. It appears the removal of long-term parasympathetic input has affected the routing of pIgR within salivary cells and reduced the SIgA transport into saliva. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：4 / 11

页数：8

共 28 条

[11] In polarized MDCK cells basolateral vesicles arise from clathrin-γ-adaptin-coated domains on endosomal tubules [J].