Enantioselective assembly of substituted dihydropyrones via organocatalytic reaction in water media

被引：103

作者：

Wang, Jing ^{[1
]}

Yu, Fang ^{[2
]}

Zhang, Xiaojing ^{[2
]}

Ma, Dawei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

[2] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1021/ol800835m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diarylprolinol ether/HOAc-catalyzed cascade Michael addition and cyclization of aldehydes and alpha-keto-alpha,beta-unsaturated esters proceeds smoothly in water to afford cyclic hemiacetals, which are oxidized to furnish highly functionalized 3,4,5,6-tetrasubstituted dihydropyrones with excellent enantioselectivities.

引用

页码：2561 / 2564

页数：4

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