Regulation of UV-induced DNA damage response by ubiquitylation

被引：26

作者：

Beryink, Steuen ^{[1
]}

Jaspers, Nicolaas G. J. ^{[1
]}

Vermeulen, Wim ^{[1
]}

机构：

[1] Erasmus MC, Dept Cell Biol & Genet, MGC CBG, NL-3000 CA Rotterdam, Netherlands

来源：

DNA REPAIR | 2007年 / 6卷 / 09期

关键词：

ubiquitin; DNA damage response; nucleotide excision repair;

D O I：

10.1016/j.dnarep.2007.01.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Like many other cellular processes, regulation of the DNA damage response (DDR) is regulated at different levels, ranging from transcriptional control to an array of distinct post-translational modifications. Involvement of ubiquitylation and the ubiquitin proteasome system in adjusting DDR are such protein modifications that were receiving increasing attention in the field. In this review we summarize and discuss a few recent key publications addressing the issue of DDR factor ubiquitylation, focusing on UV-induced DDR. We discuss the implications of these modifications to allow swift adaptation and regulation of genome surveillance factors. (C) 2007 Published by Elsevier B.V.

引用

页码：1231 / 1242

页数：12

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