A tandem cross-coupling/SNAr approach to functionalized carbazoles

被引：65

作者：

Jean, David J. St., Jr. ^{[1
]}

Poon, Steve F. ^{[1
]}

Schwarzbach, Jamie L. ^{[1
]}

机构：

[1] Amgen Inc, Dept Med Chem, Thousand Oaks, CA 91320 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 23期

关键词：

D O I：

10.1021/oI702274y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route to functionalized carbazoles utilizing a tandem Suzuki cross-coupling/SNAr protocol is described. This process was found to be compatible with a variety of electron-withdrawing groups including aldehydes, esters, and sulfones. Using this method, a concise total synthesis (four steps, 50% overall yield) of the carbazole alkaloid glycosinine was achieved.

引用

页码：4893 / 4896

页数：4

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