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A Lead(II)-Driven DNA Molecular Device for Turn-On Fluorescence Detection of Lead(II) Ion with High Selectivity and Sensitivity

被引：370
作者：
Li, Tao
Dong, Shaojun
Wang, Erkang [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 38期
基金：
中国国家自然科学基金;
关键词：
GOLD NANOPARTICLES; PB2+ DETECTION; G-QUADRUPLEX; DNAZYME; BIOSENSOR; MACHINE;
D O I：
10.1021/ja105849m
中图分类号：
O6 [化学];
学科分类号：
070301 [无机化学];
摘要：
A Pb2+-driven DNA molecular device which is constructed based on a DNA duplex quadruplex exchange is utilized for the highly selective and sensitive detection of Pb2+. The power of this DNA device originates from the excellent efficiency of Pb2+ for stabilizing G-quadruplexes, which makes the DNA duplex unwind thereby driving the device. This device can be reset to the original state by addition of a strong Pb2+ chelator DOTA, endowing the device with good reusability. In the whole process, the signal readout is modulated via a fluorescent probe binding to and being released from the G-quadruplex. Such a DNA device can serve as a novel turn-on fluorescent sensor for Pb2+ detection with high selectivity and sensitivity.
引用
收藏
页码：13156 / 13157
页数：2
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