Studies on the enantioselective synthesis of α-amino acids via asymmetric phase-transfer catalysis

被引：89

作者：

Lygo, B ^{[1
]}

Crosby, J

Lowdon, TR

Peterson, JA

Wainwright, PG

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] AstraZeneca, Proc R&D, Macclesfield SK10 2NA, Cheshire, England

[3] Hickson & Welch Ltd, Castleford WF10 2JT, W Yorkshire, England

[4] Univ Salford, Dept Chem, Salford M5 4WT, Lancs, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 12期

关键词：

alpha-amino acid; enantioselectivity; alkylation; phase-transfer; asymmetric catalysis;

D O I：

10.1016/S0040-4020(01)00094-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we describe investigations into the use of cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts for the asymmetric alkylation of a benzophenone-derived glycine-imine. Utility of this process is demonstrated by the enantioselective synthesis of a range of alpha -amino acid esters. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2403 / 2409

页数：7

共 30 条

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