Studies on the enantioselective synthesis of α-amino acids via asymmetric phase-transfer catalysis

被引:89
作者
Lygo, B [1 ]
Crosby, J
Lowdon, TR
Peterson, JA
Wainwright, PG
机构
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[2] AstraZeneca, Proc R&D, Macclesfield SK10 2NA, Cheshire, England
[3] Hickson & Welch Ltd, Castleford WF10 2JT, W Yorkshire, England
[4] Univ Salford, Dept Chem, Salford M5 4WT, Lancs, England
关键词
alpha-amino acid; enantioselectivity; alkylation; phase-transfer; asymmetric catalysis;
D O I
10.1016/S0040-4020(01)00094-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In this paper, we describe investigations into the use of cinchona alkaloid-derived quaternary ammonium phase-transfer catalysts for the asymmetric alkylation of a benzophenone-derived glycine-imine. Utility of this process is demonstrated by the enantioselective synthesis of a range of alpha -amino acid esters. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2403 / 2409
页数:7
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