Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease

被引：149

作者：

Csiszar, Anna ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Donald W Reynolds Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK 73104 USA

来源：

RESVERATROL AND HEALTH | 2011年 / 1215卷

关键词：

resveratrol; aging; vascular dysfunction; NF-KAPPA-B; SMALL-MOLECULE ACTIVATORS; OXIDATIVE STRESS; NITRIC-OXIDE; ENDOTHELIAL-CELLS; UP-REGULATION; MITOCHONDRIAL BIOGENESIS; CARDIAC DYSFUNCTION; TNF-ALPHA; SIRT1;

D O I：

10.1111/j.1749-6632.2010.05848.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cardiovascular diseases are the most common cause of death among the elderly in the Western world. Resveratrol (3,5,4'-trihydroxystilbene) is a plant-derived polyphenol that was shown to exert diverse anti-aging activity mimicking some of the molecular and functional effects of caloric restriction. This mini-review focuses on the molecular and cellular mechanisms activated by resveratrol in the vascular system, and explores the links between its anti-oxidative and anti-inflammatory effects, which could be exploited for the prevention or amelioration of vascular aging in the elderly.

引用

页码：117 / 122

页数：6

共 64 条

[61] Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: Effects on the inhibition of STAT3 phosphorylation [J].