DNA damage detection and repair, and the involvement of epigenetic states

被引：14

作者：

Bassal, S ^{[1
]}

El-Osta, A ^{[1
]}

机构：

[1] AMREP, Baker Med Res Inst, Epigenet Human Hlth & Dis Lab, Prahran, Vic 3181, Australia

来源：

HUMAN MUTATION | 2005年 / 25卷 / 02期

关键词：

DNA repair; epigenetics; pathway coordination; methylation; chromatin and transcription;

D O I：

10.1002/humu.20130

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromatin is a highly dynamic structure that acts alternately as a substrate and a template in a number of critical biological processes. Modification of chromatin is pertinent and is responsible for a number of nuclear processes, including DNA repair, replication, transcription, and recombination. The purpose of this review is to discuss specific interactions between chromatin remodeling, DNA repair, and transcription. These areas are demonstrated to share commonality, particularly with a number of key molecules that appear to have roles in a number of pathways. The implications of pathway cross-over and communication form a seamless continuation of genomic integrity and stability. (C) 2005 Wiley-Liss, Inc.

引用

页码：101 / 109

页数：9

共 90 条

[41] Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity [J].

Larochelle, S ;

Pandur, J ;

Fisher, RP ;

Salz, HK ;

Suter, B .

GENES & DEVELOPMENT, 1998, 12 (03) :370-381

[42] RETRACTED: Transcription-coupled repair of 8-oxoGuanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome (Retracted Article. See vol 123, pg 711, 2005) [J].

Le Page, F ;

Kwoh, EE ;

Avrutskaya, A ;

Gentil, A ;

Leadon, SA ;

Sarasin, A ;

Cooper, PK .

CELL, 2000, 101 (02) :159-171

[43] PURIFICATION, SEQUENCE, AND CELLULAR-LOCALIZATION OF A NOVEL CHROMOSOMAL PROTEIN THAT BINDS TO METHYLATED DNA [J].

LEWIS, JD ;

MEEHAN, RR ;

HENZEL, WJ ;

MAURERFOGY, I ;

JEPPESEN, P ;

KLEIN, F ;

BIRD, A .

CELL, 1992, 69 (06) :905-914

[44] INSTABILITY AND DECAY OF THE PRIMARY STRUCTURE OF DNA [J].

LINDAHL, T .

NATURE, 1993, 362 (6422) :709-715

[45]

MAYNE LV, 1982, CANCER RES, V42, P1473

[46] SELECTIVE REMOVAL OF TRANSCRIPTION-BLOCKING DNA DAMAGE FROM THE TRANSCRIBED STRAND OF THE MAMMALIAN DHFR GENE [J].

MELLON, I ;

SPIVAK, G ;

HANAWALT, PC .

CELL, 1987, 51 (02) :241-249

[47] DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development [J].

Merino, C ;

Reynaud, E ;

Vázquez, M ;

Zurita, M .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (09) :3246-3256

[48] 5' CPG ISLAND METHYLATION IS ASSOCIATED WITH TRANSCRIPTIONAL SILENCING OF THE TUMOR-SUPPRESSOR P16/CDKN2/MTS1 IN HUMAN CANCERS [J].

MERLO, A ;

HERMAN, JG ;

MAO, L ;

LEE, DJ ;

GABRIELSON, E ;

BURGER, PC ;

BAYLIN, SB ;

SIDRANSKY, D .

NATURE MEDICINE, 1995, 1 (07) :686-692

[49] Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification [J].

Milutinovic, S ;

Zhuang, QL ;

Szyf, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (23) :20974-20978

[50] Divide and conquer: nucleotide excision repair battles cancer and ageing [J].

Mitchell, JR ;

Hoeijmakers, JHJ ;

Niedernhofer, LJ .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (02) :232-240

← 1 2 3 4 5 6 7 8 9 →