Synthesis of substituted imidazoles via organocatalysis

被引：172

作者：

Frantz, DE

Morency, L

Soheili, A

Murry, JA

Grabowski, EJJ

Tillyer, RD

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Wayne, PA 19087 USA

[2] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 05期

关键词：

D O I：

10.1021/ol0498803

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot synthesis of substituted imidazoles is described. The cornerstone of this methodology involves the thiazolium-catalyzed addition of an aldehyde to an acyl Imine to generate the corresponding alpha-ketoamide in situ followed by ring closure to the imidazole in a one-pot sequence. The extension of this methodology to the one-pot synthesis of substituted oxazoles and thiazoles is also described.

引用

页码：843 / 846

页数：4

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