Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

被引：57

作者：

Anto, Josep M. ^{[1
,2
,3
,4
]}

Pinart, Mariona ^{[1
,2
,3
]}

Akdis, Muebeccel ^{[5
]}

Auffray, Charles ^{[6
]}

Bachert, Claus ^{[7
]}

Basagana, Xavier ^{[1
,2
,3
]}

Carlsen, Kai-Hakon ^{[8
,9
]}

Guerra, Stefano ^{[1
,2
,3
,10
]}

von Hertzen, Leena ^{[11
]}

Illi, Sabina ^{[12
]}

Kauffmann, Francine ^{[13
,14
]}

Keil, Thomas ^{[15
]}

Kiley, James P. ^{[16
]}

Koppelman, Gerard H. ^{[17
]}

Lupinek, Christian ^{[18
]}

Martinez, Fernando D. ^{[10
]}

Nawijn, Martijn C. ^{[19
]}

Postma, Dirkje S. ^{[20
]}

Siroux, Valerie ^{[21
]}

Smit, Henriette A. ^{[22
]}

Sterk, Peter J. ^{[23
,24
]}

Sunyer, Jordi ^{[1
,2
,3
,4
]}

Valenta, Rudolf ^{[18
]}

Valverde, Sergio ^{[25
]}

Akdis, Cezmi A. ^{[5
]}

Annesi-Maesano, Isabella ^{[26
,27
]}

Ballester, Ferran ^{[3
,28
,29
]}

Benet, Marta ^{[1
,2
,3
]}

Cambon-Thomsen, Anne ^{[30
,31
]}

Chatzi, Leda ^{[32
]}

Coquet, Jonathan ^{[33
]}

Demoly, Pascal ^{[34
,35
]}

Gan, Weiniu ^{[16
]}

Garcia-Aymerich, Judith ^{[1
,2
,3
,4
]}

Gimeno-Santos, Elena ^{[1
,2
,3
]}

Guihenneuc-Jouyaux, Chantal ^{[36
]}

Haahtela, Tari ^{[11
]}

Heinrich, Joachim ^{[37
]}

Herr, Marie ^{[36
]}

Hohmann, Cynthia ^{[15
]}

Jacquemin, Benedicte ^{[13
,14
]}

Just, Jocelyne ^{[36
,38
]}

Kerkhof, Marjan ^{[39
]}

Kogevinas, Manolis ^{[1
,2
,3
,40
]}

Kowalski, Marek L. ^{[41
]}

Lambrecht, Bart N. ^{[34
]}

Lau, Susanne ^{[42
]}

Carlsen, Karin C. Lodrup ^{[8
,9
]}

Maier, Dieter ^{[43
]}

Momas, Isabelle ^{[36
,44
]}

机构：

[1] CREAL Ctr Res Environm Epidemiol, Barcelona 08003, Spain

[2] Hosp Mar Res Inst IMIM, Barcelona, Spain

[3] CIBERESP, Barcelona, Spain

[4] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain

[5] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[6] CNRS Inst Biol Sci, Villejuif, France

[7] Univ Hosp Ghent, URL Upper Airways Res Lab, Ghent, Belgium

[8] Oslo Univ Hosp, Dept Paediat, Oslo, Norway

[9] Univ Oslo, N-0316 Oslo, Norway

[10] Univ Arizona, Arizona Resp Ctr, Tucson, AZ USA

[11] Helsinki Univ Hosp, Dept Allergy, Skin & Allergy Hosp, Helsinki, Finland

[12] Univ Munich, Dept Pulm & Allergy, Univ Childrens Hosp Munich, Munich, Germany

[13] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, U1018, Resp & Environm Epidemiol Team, Villejuif, France

[14] Univ Paris 11, UMRS 1018, F-94807 Villejuif, France

[15] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany

[16] NHLBI, Div Lung Dis, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[17] Univ Groningen, Dept Pediat Pulmonol & Pediat Allergol, Beatrix Childrens Hosp, GRIAC Res Inst,Univ Med Ctr Groningen, Groningen, Netherlands

[18] Med Univ Vienna, Div Immunopathol, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria

[19] Univ Groningen, Univ Med Ctr Groningen, Lab Allergol & Pulm Dis, Dept Pathol & Med Biol,GRIAC Res Inst, Groningen, Netherlands

[20] Univ Groningen, Univ Med Ctr Groningen, Dept Resp Med, Beatrix Childrens Hosp,GRIAC Res Inst, Groningen, Netherlands

[21] Univ Grenoble 1, INSERM, Team Environm Epidemiol Appl Reprod & Resp Hlth, U823, Grenoble, France

[22] Univ Utrecht, Julius Ctr Hlth Sci & Primary Care, Univ Med Ctr Utrecht, NL-3508 TC Utrecht, Netherlands

[23] Leiden Univ, Med Ctr, Dept Pulmonol, Leiden, Netherlands

[24] Univ Amsterdam, Acad Med Ctr, Dept Pulmonol, NL-1105 AZ Amsterdam, Netherlands

[25] Univ Pompeu Fabra, ICREA Complex Syst Lab, Barcelona, Spain

[26] EPAR U707 INSERM, Paris, France

[27] EPAR UMR S UPMC, Paris, France

[28] Ctr Publ Hlth Res CSISP, Div Environm & Hlth, Valencia, Spain

[29] Univ Valencia, Sch Nursing, E-46003 Valencia, Spain

[30] UMR Inserm U1027, Toulouse, France

[31] Univ Toulouse 3, F-31062 Toulouse, France

[32] Univ Crete, Dept Social Med, Iraklion, Greece

[33] Univ Ghent, Dept Resp Dis, Lab Immunoregulat & Mucosal Immunol, Ghent, Belgium

[34] World Hlth Org Collaborating Ctr Asthma & Rhiniti, Montpellier, France

[35] Hop Arnaud de Villeneuve, Univ Hosp Montpellier, Montpellier, France

[36] Paris Descartes Univ, Dept Publ Hlth & Biostat, Paris, France

[37] Helmholtz Zentrum, Inst Epidemiol 1, Munich, Germany

[38] Univ Paris 06, Grp Hosp Trousseau La Roche Guyon, APHP, Ctr Asthme & Allergies, Paris, France

[39] Univ Groningen, Dept Epidemiol, GRIAC Res Inst, Univ Med Ctr Groningen, Groningen, Netherlands

[40] Natl Sch Publ Hlth, Athens, Greece

[41] Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland

[42] Charite Campus Virchow, Dept Pneumol & Immunol, Berlin, Germany

[43] Biomax Informat AG, Munich, Germany

[44] Paris Municipal Dept Social Act Childhood & Hlth, Paris, France

[45] Bradford Teaching Hosp Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England

[46] Bradford Royal Infirm, Bradford, W Yorkshire, England

[47] EFA European Federat Allergy & Airways Dis Patien, Brussels, Belgium

[48] CHU Grenoble, F-38043 Grenoble, France

[49] Univ Grenoble 1, INSERM, U823, Inst Albert Bonniot, Grenoble, France

[50] Reg Hlth Serv Lazio Reg, Dept Epidemiol, Rome, Italy

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2012年 / 129卷 / 04期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

Allergy; Mechanisms of the Development of Allergy; Seventh Framework Program; phenotypes; IgE; asthma; WORLD-HEALTH-ORGANIZATION; T-REGULATORY-CELLS; 1ST; 6; YEARS; SEVERE ASTHMA; CLUSTER-ANALYSIS; LUNG-FUNCTION; BRONCHIAL HYPERRESPONSIVENESS; DIAGNOSTIC GATEKEEPERS; KNOWLEDGE MANAGEMENT; SYSTEMS BIOLOGY;

D O I：

10.1016/j.jaci.2012.01.047

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL. (J Allergy Clin Immunol 2012;129:943-54.)

引用

页码：943 / U421

页数：16

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