Linear Motif Atlas for Phosphorylation-Dependent Signaling

被引：358

作者：

Miller, Martin Lee ^{[2
,3
]}

Jensen, Lars Juhl ^{[3
,4
]}

Diella, Francesca ^{[4
]}

Jorgensen, Claus ^{[5
]}

Tinti, Michele ^{[6
]}

Li, Lei ^{[7
]}

Hsiung, Marilyn ^{[5
]}

Parker, Sirlester A. ^{[8
]}

Bordeaux, Jennifer ^{[8
]}

Sicheritz-Ponten, Thomas ^{[2
]}

Olhovsky, Marina ^{[5
]}

Pasculescu, Adrian ^{[5
]}

Alexander, Jes ^{[1
]}

Knapp, Stefan ^{[9
]}

Blom, Nikolaj ^{[2
]}

Bork, Peer ^{[3
,10
]}

Li, Shawn ^{[7
]}

Cesareni, Gianni ^{[6
]}

Pawson, Tony ^{[5
]}

Turk, Benjamin E. ^{[8
]}

Yaffe, Michael B. ^{[1
]}

Brunak, Soren ^{[2
,3
]}

Linding, Rune ^{[1
,5
,11
]}

机构：

[1] MIT, Ctr Canc Res, Boston, MA USA

[2] Tech Univ Denmark, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark

[3] Univ Copenhagen, Ctr Prot Res, Novo Nordisk Fdn, DK-2200 Copenhagen, Denmark

[4] European Mol Biol Lab, D-69117 Heidelberg, Germany

[5] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[6] Univ Roma Tor Vergata, I-00133 Rome, Italy

[7] Univ Western Ontario, London, ON N6A 5C1, Canada

[8] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA

[9] Univ Oxford, Struct Genom Consortium, Oxford OX3 7DQ, England

[10] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

[11] Inst Canc Res, Cellular & Mol Log Team, London SW3 6JB, England

来源：

SCIENCE SIGNALING | 2008年 / 1卷 / 35期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/scisignal.1159433

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Systematic and quantitative analysis of protein phosphorylation is revealing dynamic regulatory networks underlying cellular responses to environmental cues. However, matching these sites to the kinases that phosphorylate them and the phosphorylation-dependent binding domains that may subsequently bind to them remains a challenge. NetPhorest is an atlas of consensus sequence motifs that covers 179 kinases and 104 phosphorylation-dependent binding domains [Src homology 2 (SH2), phosphotyrosine binding (PTB), BRCA1 C-terminal (BRCT), WW, and 14-3-3]. The atlas reveals new aspects of signaling systems, including the observation that tyrosine kinases mutated in cancer have lower specificity than their non-oncogenic relatives. The resource is maintained by an automated pipeline, which uses phylogenetic trees to structure the currently available in vivo and in vitro data to derive probabilistic sequence models of linear motifs. The atlas is available as a community resource (http://netphorest.info).

引用

页数：11

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