Efflux as a mechanism for drug resistance in Mycobacterium tuberculosis

被引：151

作者：

Almeida da Silva, Pedro Eduardo ^{[1
]}

Von Groll, Andrea ^{[1
,2
]}

Martin, Anandi ^{[2
]}

Palomino, Juan Carlos ^{[2
]}

机构：

[1] Univ Fed Rio Grande, Rio Grande, Brazil

[2] Inst Trop Med, Mycobacteriol Unit, B-2000 Antwerp, Belgium

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2011年 / 63卷 / 01期

关键词：

tuberculosis; drug resistance; efflux; transporters; ATP-binding cassette; pumps; MULTIDRUG EFFLUX; ANTIBIOTIC-RESISTANCE; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; ACTIVE EFFLUX; ANTITUBERCULOSIS DRUGS; STAPHYLOCOCCUS-AUREUS; MOLECULAR-CLONING; GENE-EXPRESSION; IN-VITRO;

D O I：

10.1111/j.1574-695X.2011.00831.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tuberculosis remains an important global public health problem, with an estimated prevalence of 14 million individuals with tuberculosis worldwide in 2007. Because antibiotic treatment is one of the main tools for tuberculosis control, knowledge of Mycobacterium tuberculosis drug resistance is an important component for the disease control strategy. Although several gene mutations in specific loci of the M. tuberculosis genome have been reported as the basis for drug resistance, additional resistance mechanisms are now believed to exist. Efflux is a ubiquitous mechanism responsible for intrinsic and acquired drug resistance in prokaryotic and eukaryotic cells. Mycobacterium tuberculosis presents one of the largest numbers of putative drug efflux pumps compared with its genome size. Bioinformatics as well as direct and indirect evidence have established relationships among drug efflux with intrinsic or acquired resistance in M. tuberculosis. This minireview describes the current knowledge on drug efflux in M. tuberculosis.

引用

页码：1 / 9

页数：9

共 95 条

[21] Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis [J].