Leveraging models of cell regulation and GWAS data in integrative network-based association studies

被引：187

作者：

Califano, Andrea ^{[1
,2
,3
]}

Butte, Atul J. ^{[4
,5
]}

Friend, Stephen ^{[6
]}

Ideker, Trey ^{[7
,8
,9
]}

Schadt, Eric ^{[10
]}

机构：

[1] Columbia Univ, Columbia Initiat Syst Biol, New York, NY 10027 USA

[2] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY USA

[3] Columbia Univ, Dept Biomed Informat, New York, NY USA

[4] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

[5] Stanford Univ, Ctr Pediat Bioinformat, Lucile Packard Childrens Hosp, Stanford, CA 94305 USA

[6] Sage Bionetworks, Seattle, WA USA

[7] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[9] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA

[10] Mt Sinai Sch Med, Inst Genom & Multiscale Biol, New York, NY USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 08期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; GENE-EXPRESSION; PROTEIN-INTERACTION; MOLECULAR NETWORKS; PREDICTION; PATHWAYS; MAP; PROLIFERATION; PERTURBATION; MECHANISMS;

D O I：

10.1038/ng.2355

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

[No abstract available]

引用

页码：841 / 847

页数：7

共 87 条

[1] An Integrated Approach to Uncover Drivers of Cancer [J].

Akavia, Uri David ;

Litvin, Oren ;

Kim, Jessica ;

Sanchez-Garcia, Felix ;

Kotliar, Dylan ;

Causton, Helen C. ;

Pochanard, Panisa ;

Mozes, Eyal ;

Garraway, Levi A. ;

Pe'er, Dana .

CELL, 2010, 143 (06) :1005-1017

[2] Genetic Mapping in Human Disease [J].

Altshuler, David ;

Daly, Mark J. ;

Lander, Eric S. .

SCIENCE, 2008, 322 (5903) :881-888

[3] Rewiring of Genetic Networks in Response to DNA Damage [J].

Bandyopadhyay, Sourav ;

Mehta, Monika ;

Kuo, Dwight ;

Sung, Min-Kyung ;

Chuang, Ryan ;

Jaehnig, Eric J. ;

Bodenmiller, Bernd ;

Licon, Katherine ;

Copeland, Wilbert ;

Shales, Michael ;

Fiedler, Dorothea ;

Dutkowski, Janusz ;

Guenole, Aude ;

van Attikum, Haico ;

Shokat, Kevan M. ;

Kolodner, Richard D. ;

Huh, Won-Ki ;

Aebersold, Ruedi ;

Keogh, Michael-Christopher ;

Krogan, Nevan J. ;

Ideker, Trey .

SCIENCE, 2010, 330 (6009) :1385-1389

[4] A human MAP kinase interactome [J].

Bandyopadhyay, Sourav ;

Chiang, Chih-yuan ;

Srivastava, Jyoti ;

Gersten, Merril ;

White, Suhaila ;

Bell, Russell ;

Kurschner, Cornelia ;

Martin, Christopher H. ;

Smoot, Mike ;

Sahasrabudhe, Sudhir ;

Barber, Diane L. ;

Chanda, Sumit K. ;

Ideker, Trey .

NATURE METHODS, 2010, 7 (10) :801-U50

[5] Reverse engineering of regulatory networks in human B cells [J].

Basso, K ;

Margolin, AA ;

Stolovitzky, G ;

Klein, U ;

Dalla-Favera, R ;

Califano, A .

NATURE GENETICS, 2005, 37 (04) :382-390

[6] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

[7] Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses [J].

Birtwistle, Marc R. ;

Hatakeyama, Mariko ;

Yumoto, Noriko ;

Ogunnaike, Babatunde A. ;

Hoek, Jan B. ;

Kholodenko, Boris N. .

MOLECULAR SYSTEMS BIOLOGY, 2007, 3 (1)

[8] A network-based analysis of systemic inflammation in humans [J].

Calvano, SE ;

Xiao, WZ ;

Richards, DR ;

Felciano, RM ;

Baker, HV ;

Cho, RJ ;

Chen, RO ;

Brownstein, BH ;

Cobb, JP ;

Tschoeke, SK ;

Miller-Graziano, C ;

Moldawer, LL ;

Mindrinos, MN ;

Davis, RW ;

Tompkins, RG ;

Lowry, SF .

NATURE, 2005, 437 (7061) :1032-1037

[9] The transcriptional network for mesenchymal transformation of brain tumours [J].

Carro, Maria Stella ;

Lim, Wei Keat ;

Alvarez, Mariano Javier ;

Bollo, Robert J. ;

Zhao, Xudong ;

Snyder, Evan Y. ;

Sulman, Erik P. ;

Anne, Sandrine L. ;

Doetsch, Fiona ;

Colman, Howard ;

Lasorella, Anna ;

Aldape, Ken ;

Califano, Andrea ;

Iavarone, Antonio .

NATURE, 2010, 463 (7279) :318-U68

[10] Interaction networks: From protein functions to drug discovery. A review [J].

Chautard, E. ;

Thierry-Mieg, N. ;

Ricard-Blum, S. .

PATHOLOGIE BIOLOGIE, 2009, 57 (04) :324-333

← 1 2 3 4 5 6 7 8 9 →