Leveraging models of cell regulation and GWAS data in integrative network-based association studies

被引：187

作者：

Califano, Andrea ^{[1
,2
,3
]}

Butte, Atul J. ^{[4
,5
]}

Friend, Stephen ^{[6
]}

Ideker, Trey ^{[7
,8
,9
]}

Schadt, Eric ^{[10
]}

机构：

[1] Columbia Univ, Columbia Initiat Syst Biol, New York, NY 10027 USA

[2] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY USA

[3] Columbia Univ, Dept Biomed Informat, New York, NY USA

[4] Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA

[5] Stanford Univ, Ctr Pediat Bioinformat, Lucile Packard Childrens Hosp, Stanford, CA 94305 USA

[6] Sage Bionetworks, Seattle, WA USA

[7] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[9] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA

[10] Mt Sinai Sch Med, Inst Genom & Multiscale Biol, New York, NY USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 08期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; GENE-EXPRESSION; PROTEIN-INTERACTION; MOLECULAR NETWORKS; PREDICTION; PATHWAYS; MAP; PROLIFERATION; PERTURBATION; MECHANISMS;

D O I：

10.1038/ng.2355

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

[No abstract available]

引用

页码：841 / 847

页数：7

共 87 条

[21] Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism [J].

Ferron, Mathieu ;

Wei, Jianwen ;

Yoshizawa, Tatsuya ;

Del Fattore, Andrea ;

DePinho, Ronald A. ;

Teti, Anna ;

Ducy, Patricia ;

Karsenty, Gerard .

CELL, 2010, 142 (02) :296-308

[22] Inferring cellular networks using probabilistic graphical models [J].

Friedman, N .

SCIENCE, 2004, 303 (5659) :799-805

[23] Inferring genetic networks and identifying compound mode of action via expression profiling [J].

Gardner, TS ;

di Bernardo, D ;

Lorenz, D ;

Collins, JJ .

SCIENCE, 2003, 301 (5629) :102-105

[24] Common Genetic Variation and Human Traits [J].

Goldstein, David B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (17) :1696-1698

[25] lincRNAs act in the circuitry controlling pluripotency and differentiation [J].

Guttman, Mitchell ;

Donaghey, Julie ;

Carey, Bryce W. ;

Garber, Manuel ;

Grenier, Jennifer K. ;

Munson, Glen ;

Young, Geneva ;

Lucas, Anne Bergstrom ;

Ach, Robert ;

Bruhn, Laurakay ;

Yang, Xiaoping ;

Amit, Ido ;

Meissner, Alexander ;

Regev, Aviv ;

Rinn, John L. ;

Root, David E. ;

Lander, Eric S. .

NATURE, 2011, 477 (7364) :295-U60

[26] Genome-Wide Association Data Reveal a Global Map of Genetic Interactions among Protein Complexes [J].

Hannum, Gregory ;

Srivas, Rohith ;

Guenole, Aude ;

van Attikum, Haico ;

Krogan, Nevan J. ;

Karp, Richard M. ;

Ideker, Trey .

PLOS GENETICS, 2009, 5 (12)

[27] CURRENT CONCEPTS Genomewide Association Studies and Human Disease [J].

Hardy, John ;

Singleton, Andrew .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (17) :1759-1768

[28] A study of miRNAs targets prediction and experimental validation [J].

Huang, Yong ;

Zou, Quan ;

Song, Haitai ;

Song, Fei ;

Wang, Ligang ;

Zhang, Guozheng ;

Shen, Xingjia .

PROTEIN & CELL, 2010, 1 (11) :979-986

[29]

Ideker Trey, 2002, Bioinformatics, V18 Suppl 1, pS233

[30] A Bayesian networks approach for predicting protein-protein interactions from genomic data [J].

Jansen, R ;

Yu, HY ;

Greenbaum, D ;

Kluger, Y ;

Krogan, NJ ;

Chung, SB ;

Emili, A ;

Snyder, M ;

Greenblatt, JF ;

Gerstein, M .

SCIENCE, 2003, 302 (5644) :449-453

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