Cucurbitane Triterpenoids from Momordica charantia and Their Cytoprotective Activity in tert-Butyl Hydroperoxide-Induced Hepatotoxicity of HepG2 Cells

被引：32

作者：

Chen, Chiy-Rong ^{[2
]}

Liao, Yun-Wen ^{[1
]}

Wang, Lai ^{[1
]}

Kuo, Yueh-Hsiung ^{[3
]}

Liu, Hung-Jen ^{[4
]}

Shih, Wen-Ling ^{[1
]}

Cheng, Hsueh-Ling ^{[1
]}

Chang, Chi-I ^{[1
]}

机构：

[1] Natl Pingtung Univ Sci & Technol, Grad Inst Biotechnol, Pingtung 91201, Taiwan

[2] Meiho Univ, Dept Biol Sci & Technol, Pingtung 91201, Taiwan

[3] China Med Univ, Tsuzuki Inst Tradit Med, Coll Pharm, Taichung 40402, Taiwan

[4] Natl Chung Hsing Univ, Inst Mol Biol, Taichung 40227, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 12期

关键词：

Chinese herb; Momordica charantia; Cucurbitaceae; pentanorcucurbitane; trinorcucurbitane; cytoprotective; GLYCOSIDES; CONSTITUENTS; FRUIT; STEMS;

D O I：

10.1248/cpb.58.1639

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-mc acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.

引用

页码：1639 / 1642

页数：4

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