Octanorcucurbitane Triterpenoids Protect against tert-Butyl Hydroperoxide-Induced Hepatotoxicity from the Stems of Momordica charantia

被引：19

作者：

Chang, Chi-I ^{[1
]}

Chen, Chiy-Rong ^{[2
]}

Liao, Yun-Wen ^{[1
]}

Shih, Wen-Ling ^{[1
]}

Cheng, Hsueh-Ling ^{[1
]}

Tzeng, Chih-Ying ^{[1
]}

Li, Jia-Wei ^{[2
]}

Kung, Ming-Ting ^{[2
]}

机构：

[1] Natl Pingtung Univ Sci & Technol, Grad Inst Biotechnol, Pingtung 91201, Taiwan

[2] Meiho Inst Technol, Dept Biol Sci & Technol, Pingtung 91201, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 02期

关键词：

Momordica charantia; Cucurbitaceae; octanorcucurbitane; tert-butyl hydroperoxide; cytotoxic; CUCURBITANE-TYPE TRITERPENOIDS; GLYCOSIDES; CONSTITUENTS; FRUIT;

D O I：

10.1248/cpb.58.225

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Four novel octanorcucurbitane triterpenes, octanorcucurbitacins A-D (1-4), together with one known octanorcucurbitane triterpene, kuguacin M (5), were isolated from the methyl alcohol extract of the stems of Momordica charantia. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compound 3 inhibited tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity against HepG2 cells.

引用

页码：225 / 229

页数：5

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