Extraordinary metabolic stability of peptides containing α-aminoxy acids

被引：25

作者：

Chen, Fei ^{[1
]}

Ma, Bin ^{[2
]}

Yang, Zong-Chang ^{[1
]}

Lin, Ge ^{[2
]}

Yang, Dan ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

来源：

AMINO ACIDS | 2012年 / 43卷 / 01期

关键词：

Metabolism; Peptides; Stability; Aminoxy acid; BETA-PEPTIDES; BIOLOGICAL STABILITY; CYCLIC HEXAPEPTIDE; CHLORIDE-ION; IN-VITRO; FOLDAMERS; RECEPTOR; TURNS; HELICES; CHANNELS;

D O I：

10.1007/s00726-011-1095-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The metabolic stability of peptides containing a mixed sequence of alpha-aminoxy acids and alpha-amino acids is significantly improved compared to peptides composed of only natural alpha-amino acids. The introduction of an alpha-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing alpha-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

引用

页码：499 / 503

页数：5

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