Tumor suppressor function of RUNX3 in breast cancer

被引：51

作者：

Chen, Lin-Feng ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Biochem, Urbana, IL 61801 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2012年 / 113卷 / 05期

关键词：

BREAST CANCER; ESTROGEN RECEPTOR; INACTIVATION; RUNX3; TUMOR SUPPRESSOR; ESTROGEN-RECEPTOR-ALPHA; DNA METHYLATION; GASTRIC-CANCER; PROMOTER HYPERMETHYLATION; KINASE PHOSPHORYLATES; STEM-CELLS; PROTEIN; BETA; EXPRESSION; GENE;

D O I：

10.1002/jcb.24074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Emerging evidence indicates that RUNX3 is a tumor suppressor in breast cancer. RUNX3 is frequently inactivated in human breast cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. Inactivation of RUNX3 is associated with the initiation and progression of breast cancer. Female Runx3+/- mice spontaneously develop ductal carcinoma, and overexpression of RUNX3 inhibits the proliferation, tumorigenic potential, and invasiveness of breast cancer cells. This review is intended to summarize these findings and discuss the tumor suppressor function of RUNX3 in breast cancer. J. Cell. Biochem. 113: 14701477, 2012. (C) 2012 Wiley Periodicals, Inc.

引用

页码：1470 / 1477

页数：8

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