Cannabinoids inhibit neurodegeneration in models of multiple sclerosis

被引：270

作者：

Pryce, G

Ahmed, Z

Hankey, DJR

Jackson, SJ

Croxford, JL

Pocock, JM

Ledent, C

Petzold, A

Thompson, AJ

Giovannoni, G

Cuzner, ML

Baker, D

机构：

[1] UCL, Inst Neurol, Dept Neuroinflammat, London WC1N 1PJ, England

[2] Free Univ Brussels, Inst Rech Interdisciplinaire Biol Humaine & Mol, Brussels, Belgium

[3] UCL, Inst Neurol, Neurorehabil Grp, London, England

来源：

BRAIN | 2003年 / 126卷

关键词：

cannabinoids; excitotoxicity; experimental allergic encephalomyelitis; multiple sclerosis; neuroprotection;

D O I：

10.1093/brain/awg224

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model of multiple sclerosis, we demonstrate that the cannabinoid system is neuroprotective during EAE. Mice deficient in the cannabinoid receptor CB(1) tolerate inflammatory and excito toxic insults poorly and develop substantial neurodegeneration following immune attack in EAE. In addition, exogenous CB(1) agonists can provide significant neuroprotection from the consequences of inflammatory CNS disease in an experimental allergic uveitis model. Therefore, in addition to symptom management, cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other diseases.

引用

页码：2191 / 2202

页数：12

共 71 条

[31] Interphotoreceptor retinoid binding protein peptide-induced uveitis in B10.RIII mice: Characterization of disease parameters and immunomodulation [J].