Nanogel-quantum dot hybrid nanoparticles for live cell imaging

被引：171

作者：

Hasegawa, U

Nomura, SIM

Kaul, SC

Hirano, T

Akiyoshi, K

机构：

[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan

[2] Tokyo Med & Dent Univ, Ctr Excellence Program Frontier Res Mol Destruct, Chiyoda Ku, Tokyo 1010062, Japan

[3] AIST, Tsukuba, Ibaraki 3058562, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 331卷 / 04期

关键词：

cholesterol-bearing pullulan; nanogel; quantum dot; bioimaging; live cell labeling; cellular uptake; carrier; cationic liposome;

D O I：

10.1016/j.bbrc.2005.03.228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here a novel carrier of quantum dots (QDs) for intracellular labeling. Monodisperse hybrid nanoparticles (38 nm in diameter) of QDs were prepared by simple mixing with nanogels of cholesterol-bearing pullulan (CHP) modified with amino groups (CHPNH2). The CHPNH2-QD nanoparticles were effectively internalized into the various human cells examined. The efficiency of cellular uptake was much higher than that of a conventional carrier, cationic liposome. These hybrid nanoparticles could be a promising fluorescent probe for bioimaging. (c) 2005 Elsevier Inc. All rights reserved.

引用

收藏

页码：917 / 921

页数：5

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