Parallel synthesis of homochiral β-amino acids

被引：45

作者：

Davies, Stephen G. ^{[1
]}

Mulvaney, Andrew W. ^{[1
]}

Russell, Angela J. ^{[1
]}

Smith, Andrew D. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Organ Chem, Oxford OX1 3TA, England

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 13期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.tetasy.2007.06.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The parallel asymmetric synthesis of an array of 30 P-amino acids of high enantiomeric purity using the conjugate addition of homochiral lithium N-benzyl-N-(alpha-methylbenzyl)amide as the key step is accomplished. The experimental simplicity and highly practical nature of the protocol is demonstrated by the efficient parallel conversion of 15 alpha,beta-unsaturated esters to both enantiomeric series of the corresponding beta-amino acids in high overall yields and selectivities with minimal purification involved in each step of the reaction protocol. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1554 / 1566

页数：13

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