Comparison of structure extraction methods for in vivo trabecular bone measurements

被引:137
作者
Laib, A [1 ]
Rüegsegger, P [1 ]
机构
[1] Univ Zurich, Inst Biomed Engn, CH-8044 Zurich, Switzerland
关键词
computed tomography; bone microarchitecture; trabecular bone structure; quantitative bone morphology;
D O I
10.1016/S0895-6111(98)00071-8
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In vivo trabecular bone structure measurements have become available recently using high resolution quantitative computed tomography (3D-QCT) or magnetic resonance imaging. In this work different structure extraction and morphometric evaluation techniques are compared, which are of potential use for in vivo assessment of human cancellous bone structure. Given the spatial resolution of actual in vivo examination procedures, best results are obtained by extracting first the skeleton of the structure and applying model independent 3D techniques to calculate trabecular number, then deriving mean trabecular thickness and separation from densitometric hone volume fraction and Tb.N*. Traditional histomorphometric methods based on bone surface and volume ratios and assuming a plate model performed less well. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:69 / 74
页数:6
相关论文
共 18 条
  • [1] 3D COMPUTED X-RAY TOMOGRAPHY OF HUMAN CANCELLOUS BONE AT 8 MU-M SPATIAL AND 10(-4) ENERGY RESOLUTION
    BONSE, U
    BUSCH, F
    GUNNEWIG, O
    BECKMANN, F
    PAHL, R
    DELLING, G
    HAHN, M
    GRAEFF, W
    [J]. BONE AND MINERAL, 1994, 25 (01): : 25 - 38
  • [2] DEQUEKER J, 1994, CLIN RHEUMATOL, V13, P7
  • [3] RIDGES AND VALLEYS ON DIGITAL IMAGES
    HARALICK, RM
    [J]. COMPUTER VISION GRAPHICS AND IMAGE PROCESSING, 1983, 22 (01): : 28 - 38
  • [4] A new method for the model-independent assessment of thickness in three-dimensional images
    Hildebrand, T
    Ruegsegger, P
    [J]. JOURNAL OF MICROSCOPY-OXFORD, 1997, 185 : 67 - 75
  • [5] Hipp JA, 1996, J BONE MINER RES, V11, P286
  • [6] X-RAY TOMOGRAPHIC MICROSCOPY (XTM) USING SYNCHROTRON RADIATION
    KINNEY, JH
    NICHOLS, MC
    [J]. ANNUAL REVIEW OF MATERIALS SCIENCE, 1992, 22 : 121 - 152
  • [7] THE ROLE OF 3-DIMENSIONAL TRABECULAR MICROSTRUCTURE IN THE PATHOGENESIS OF VERTEBRAL COMPRESSION FRACTURES
    KLEEREKOPER, M
    VILLANUEVA, AR
    STANCIU, J
    RAO, DS
    PARFITT, AM
    [J]. CALCIFIED TISSUE INTERNATIONAL, 1985, 37 (06) : 594 - 597
  • [8] Ridge number density:: A new parameter for in vivo bone structure analysis
    Laib, A
    Hildebrand, T
    Häuselmann, HJ
    Rüegsegger, P
    [J]. BONE, 1997, 21 (06) : 541 - 546
  • [9] Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-μm-resolution microcomputed tomography
    Laib, A
    Rüegsegger, P
    [J]. BONE, 1999, 24 (01) : 35 - 39
  • [10] Lorensen W. E., 1987, COMPUT GRAPH, V21, P163, DOI DOI 10.1145/37402.37422