Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

被引：52

作者：

Allen, Olivia R.

Gott, Andrew L.

Hartley, John A.

Hartley, Janet M.

Knox, Richard J.

McGowan, Patrick C. ^{[1
]}

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Prother PLC, Salisbury SP4 0JQ, Wilts, England

[3] UCL, Royal Free & Univ Coll London, Dept Oncol, Canc Res UK Drug DNA Interact Res Grp, London W1W 7BS, England

来源：

DALTON TRANSACTIONS | 2007年 / 43期

关键词：

D O I：

10.1039/b708283p

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A number of new ionic titanocene compounds have been isolated and characterised, which exhibit excellent cytotoxicity against different human tumour cell lines including a defined cisplatin resistant cell line. A range of biological assays have been carried out to determine levels of cytotoxicity and levels of DNA interstrand crosslinking.

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页码：5082 / 5090

页数：9

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