Genetic diversity of carbapenem-hydrolysing β-lactamases in Acinetobacter baumannii from Romanian hospitals

被引：37

作者：

Bonnin, R. A. ^{[1
,2
]}

Poirel, L. ^{[1
,2
]}

Licker, M. ^{[3
]}

Nordmann, P. ^{[1
,2
]}

机构：

[1] Univ Paris 11, K Bicetre, France

[2] Hop Bicetre, Assistance Publ HopParis, Serv Bacteriol Virol, Fac Med,INSERM Emerging Resistance Antibiot U914, K Bicetre, France

[3] Univ Med & Farm Timisoara, Dept Microbiol, Timisoara, Romania

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 10期

关键词：

Acinetobacter baumannii; carbapenemase; extended-spectrum beta-lactamase; OXA-23; OXA-58; MULTIDRUG-RESISTANCE; NOSOCOMIAL SPREAD; OXACILLINASE; EMERGENCE; OUTBREAK; MECHANISMS; EXPRESSION; STRAINS; OXA-58;

D O I：

10.1111/j.1469-0691.2011.03622.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Thirteen carbapenem-resistant Acinetobacter baumannii isolates, collected in Romania during 2009-2010, were investigated to identify the mechanism(s) responsible for carbapenem resistance. Genotyping was performed by pulsed-field gel electrophoresis, multiplex PCR sequence typing and multilocus sequence typing. Eleven non-clonally related isolates harboured the bla(OXA-23) gene on their chromosome within a Tn2008 transposon structure. The two remaining isolates harboured a bla(OXA-58) gene that was either plasmid or chromosome borne. Two isolates co-expressed OXA-23 together with the extended-spectrum beta-lactamase PER-1. This study constitutes the first report of OXA-58 and OXA-23-producing A. baumannii isolates in Romania.

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收藏

页码：1524 / 1528

页数：6

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