Synthesis and biological evaluation of ebselen and its acyclic derivatives

被引：31

作者：

Chang, TC

Huang, ML

Hsu, WL

Hwang, JM

Hsu, LY

机构：

[1] Natl Def Med Ctr, Sch Pharm, Taipei, Taiwan

[2] Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan

[3] Tri Serv Gen Hosp, Dept Radiat Oncol, Taipei 114, Taiwan

[4] Buddhist Tzu Chi Med Ctr, Canc Med Ctr, Hualien, Taiwan

[5] Buddhist Tzu Chi Med Ctr, Dept Radiat Oncol, Hualien, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 12期

关键词：

ebselen derivative; selenoorganic compound; antioxidant; peroxynitrite; glutathione peroxidase;

D O I：

10.1248/cpb.51.1413

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.

引用

页码：1413 / 1416

页数：4

共 16 条

[1] Antioxidant actions of ovothiol-derived 4-mercaptoimidazoles: glutathione peroxidase activity and protection against peroxynitrite-induced damage [J].