New one pot synthesis of a chiral α-hydroxy-γ-butyrolactone via sequential asymmetric hydrogenation of an α,γ-diketoester

被引：19

作者：

Blandin, V ^{[1
]}

Carpentier, JF ^{[1
]}

Mortreux, A ^{[1
]}

机构：

[1] ENSCL, Grp Chim Organ Appl, CNRS, Catalyse Heterogene & Homogene Lab, F-59652 Villeneuve Dascq, France

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0957-4166(98)00281-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The hydrogenation of ethyl 2,4-dioxovalerate in the presence of chiral rhodium or ruthenium catalysts provides direct access to 2-hydroxy-4-methyltetrahydrofuran-2-one 4 with syn:anti ratios of up to 84:16 and with up to 98% and 94% e.e. in the syn and anti form, respectively. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2765 / 2768

页数：4

共 14 条

[11] PREPARATION OF 2,2-DICHLORO-3(2H)-FURANONE AND ITS REACTIONS WITH HETERONUCLEOPHILES [J].