The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria

被引：24

作者：

Fuentes, DE

Navarro, CA

Tantaleán, JC

Araya, MA

Saavedra, CP

Pérez, JM

Calderón, IL

Youderian, PA

Mora, GC

Vásquez, CC

机构：

[1] Univ Santiago De Chile, Fac Quim & Biol, Dept Ciencias Biol, Mol Microbiol Lab, Santiago, Chile

[2] Univ San Luis Gonzaga Ica, Fac Ciencias, Lab Microbiol Ind & Biotecnol, Ica, Peru

[3] Univ Andres Bello, Dept Ciencias Biol, Santiago, Chile

[4] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA

来源：

RESEARCH IN MICROBIOLOGY | 2005年 / 156卷 / 04期

关键词：

multidrug resistance; Staphylococcus epidermidis; beta-lactam resistance; ethidium bromide; SMR;

D O I：

10.1016/j.resmic.2005.01.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of beta-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to beta-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the beta-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：472 / 477

页数：6

共 16 条

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