Outbreak of OXA-48-Positive Carbapenem-Resistant Klebsiella pneumoniae Isolates in France

被引：172

作者：

Cuzon, Gaelle ^{[1
]}

Ouanich, Jocelyne ^{[2
]}

Gondret, Remy ^{[3
]}

Naas, Thierry ^{[1
]}

Nordmann, Patrice ^{[1
]}

机构：

[1] Univ Paris Sud, Hop Bicetre, AP HP,INSERM Emerging Resistance Antibiot U914, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Ctr Hosp Intercommunal Villeneuve St Georg, Microbiol Lab, Villeneuve St Georges, France

[3] Ctr Hosp Intercommunal Villeneuve St Georg, Serv Anesthesie Reanimat, Villeneuve St Georges, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 05期

关键词：

OXACILLINASE-MEDIATED RESISTANCE; BETA-LACTAMASE; IMIPENEM; PLASMID; ISTANBUL; SPREAD; OXA-48;

D O I：

10.1128/AAC.01452-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Seventeen Klebsiella pneumoniae isolates producing the OXA-48 carbapenemase, obtained from 10 patients hospitalized from April to June 2010, mostly in the medical intensive care unit of the Villeneuve-Saint-Georges Hospital in a suburb of Paris, France, were analyzed. Seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. Molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the bla(OXA-48) gene and coproduced CTX-M-15 and TEM-1 beta-lactamases. This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France.

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页码：2420 / 2423

页数：4

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