Rabbit muscle aldolase (RAMA) as a catalyst in a new approach for the synthesis of 3-deoxy-D-manno-2-octulosonic acid and analogues

被引：14

作者：

Crestia, D ^{[1
]}

Guérard, C ^{[1
]}

Bolte, J ^{[1
]}

Demuynck, C ^{[1
]}

机构：

[1] Univ Blaise Pascal, Lab Chim Org Biol, UMR CNRS 6504, F-63177 Clermont Ferrand, France

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2001年 / 11卷 / 4-6期

关键词：

carbon-carbon bond formation; aldolase; KDO; KDO analogues;

D O I：

10.1016/S1381-1177(00)00074-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new approach leading to 3-deoxy-D-manno-2-octulosonic acid (KDO) and 4-deoxy-KDO is described. The key step is the formation of the C-5-C-6 bond catalysed by fructose-1,6-bisphosphate aldolase, which controls the stereochemistry of these two centres. The important step of the aldehyde substrates (la, Ib, Ic) synthesis is the Barbier reaction of ethyl-bromomethylacrylate or bromomethylacrylonitrile with the monoacetal of glyoxal in the presence of indium. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：207 / 212

页数：6

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