Advances in Coating Chemistry in Deriving Soluble Functional Nanoparticle

被引:85
作者
Basiruddin, S. K. [1 ]
Saha, Arindam [1 ]
Pradhan, Narayan [1 ]
Jana, Nikhil R. [1 ]
机构
[1] Indian Assoc Cultivat Sci, Ctr Adv Mat, Kolkata 700032, India
关键词
CDSE/CDS CORE/SHELL NANOCRYSTALS; QUANTUM DOTS; SEMICONDUCTOR NANOCRYSTALS; GOLD NANOPARTICLES; SURFACE MODIFICATION; AMPHIPHILIC POLYMER; SCALE SYNTHESIS; SIZE; NANORODS; FLUORESCENT;
D O I
10.1021/jp100844d
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Nanoparticle-based probes are emerging as alternatives to molecular probes with several advantages. A variety of water-soluble functional nanoparticles and nanobioconjugates need to be prepared and tested for this research. Development of appropriate coating chemistries is the key in deriving such functional nanoparticles. Herein we summarize different coating approaches those we have developed and compared them in the context of currently available coating methods, for the synthesis of soluble functional nanoparticles. We have focused on conventional ligand exchange, interdigited bilayer strategy, silica coating, polyacrylate coating, and imidazole based polymer coating and found that cross-linked coating, specifically by polyacrylate, provides a superior colloidal stability of nanoparticles. The robust coating provides the opportunity to explore various conjugation chemistries involving nanoparticle and to derive different soluble nanobioconjugates. A library of functional nanoprobes with hydrodynamic diameters of 10-100 nm are synthesized with these coating approaches which are composed of different nanoparticles (e.g., metal, metal oxide, or semiconductor) and affinity molecules (e.g., oligonucleotide, peptide, antibody, vitamins, etc.) and can be explored for cellular and subcellular imaging and ultrasensitive biosensing applications.
引用
收藏
页码:11009 / 11017
页数:9
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