Polyhydroxylated Steroidal Glycosides from Paris polyphylla

被引：68

作者：

Kang, Li-Ping ^{[1
,2
]}

Liu, Yi-Xun ^{[1
,3
]}

Eichhorn, Tolga ^{[4
]}

Dapat, Else ^{[4
]}

Yu, He-shui ^{[1
,2
]}

Zhao, Yang ^{[1
]}

Xiong, Cheng-Qi ^{[1
]}

Liu, Chao ^{[1
]}

Efferth, Thomas ^{[4
]}

Ma, Bai-Ping ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Beijing 100850, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China

[3] Univ S China, Inst Pharmacol & Pharm, Hengyang 421001, Peoples R China

[4] Univ Main, Inst Pharm & Biochem, Dept Pharmaceut Biol, D-55128 Mainz, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 06期

关键词：

CELL-LINES; SAPONINS; RHIZOME;

D O I：

10.1021/np300045g

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Three new steroidal saponins, parisyunnanosides G-I (1-3), one new C-21 steroidal glycoside, parisyunnanoside J (4), and three known compounds, padelaoside B (5), pinnatasterone (6), and 20-hydroxyecdyson (7), were isolated from the rhizomes of Paris polyphylla Smith var. yunnanensis. Compounds 1 and 3 have unique trisdesmoside structures that include a C-21 beta-D-galactopyranose moiety. All compounds were evaluated for their cytotoxicity against human CCRF leukemia cells.

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收藏

页码：1201 / 1205

页数：5

相关论文

共 17 条

[1]

Antifungal Saponins from Paris polyphylla Smith [J].

Deng, Dawei ;

Lauren, Denis R. ;

Cooney, Janine M. ;

Jensen, Dwayne J. ;

Wurms, Kirstin V. ;

Upritchard, Jenine E. ;

Cannon, Richard D. ;

Wang, Ming Zhong ;

Li, Ming Zhang .

PLANTA MEDICA, 2008, 74 (11) :1397-1402

[2]

Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells [J].

Efferth, T ;

Davey, M ;

Olbrich, A ;

Rücker, G ;

Gebhart, E ;

Davey, R .

BLOOD CELLS MOLECULES AND DISEASES, 2002, 28 (02) :160-168

[3]

Pennogenin glycosides with a spirostanol structure are strong platelet agonists: structural requirement for activity and mode of platelet agonist synergism [J].

Fu, Y. . -L . ;

Yu, Z. -Y. ;

Tang, X. -M. ;

Zhao, Y. ;

Yuan, X.-L. ;

Wang, S. ;

Ma, B. -P . ;

Cong, Y. -W. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (03) :524-533

[4]

Active pharmaceutical ingredients and mechanisms underlying phasic myometrial contractions stimulated with the saponin extract from Paris polyphylla Sm. var. yunnanensis used for abnormal uterine bleeding [J].

Guo, L. ;

Su, J. ;

Deng, B. W. ;

Yu, Z. Y. ;

Kang, L. P. ;

Zhao, Z. H. ;

Shan, Y. J. ;

Chen, J. P. ;

Ma, B. P. ;

Cong, Y. W. .

HUMAN REPRODUCTION, 2008, 23 (04) :964-971

[5]

Steroidal saponins from the roots of Trillium erectum (Beth root) [J].

Hayes, Patricia Y. ;

Lehmann, Reg ;

Penman, Kerry ;

Kitching, William ;

De Voss, James J. .

PHYTOCHEMISTRY, 2009, 70 (01) :105-113

[6]

[黄贤校 HUANG Xian-xiao], 2009, [中草药, Chinese Traditional and Herbal Drugs], V40, P483

[7]

Separation and identification of steroidal compounds with cytotoxic activity against human gastric cancer cell lines in vitro from the rhizomes of Paris polyphylla var. chinensis [J].

Huang Yun ;

Cui Lijian ;

Zhan Wenhong ;

Dou Yuhong ;

Wang Yongli ;

Wang Qiang ;

Zhao Ding .

CHEMISTRY OF NATURAL COMPOUNDS, 2007, 43 (06) :672-677

[8]

Steroidal Saponins from Two Species of Dracaena [J].

Kougan, Guy Beddos ;

Miyamoto, Tomofumi ;

Tanaka, Chiaki ;

Paululat, Thomas ;

Mirjolet, Jean-Francois ;

Duchamp, Olivier ;

Sondengam, Beibam Lucas ;

Lacaille-Dubois, Marie-Aleth .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (07) :1266-1270

[9]

Antibacterial Activity and Cytotoxicity of Selected Egyptian Medicinal Plants [J].

Kuete, Victor ;

Wiench, Benjamin ;

Hegazy, Mohamed-Elamir F. ;

Mohamed, Tank A. ;

Fankam, Aime G. ;

Shahat, Abdelaaty A. ;

Efferth, Thomas .

PLANTA MEDICA, 2012, 78 (02) :193-199

[10]

Spirostanol Saponins Derivated from the Seeds of Trigonella foenum-graecum by β-Glucosidase Hydrolysis and Their Inhibitory Effects on Rat Platelet Aggregation [J].

Pang, Xu ;

Cong, Yue ;

Yu, He-Shui ;

Kang, Li-Ping ;

Feng, Bing ;

Han, Bing-Xing ;

Zhao, Yang ;

Xiong, Cheng-Qi ;

Tan, Da-Wei ;

Song, Wei ;

Liu, Bin ;

Cong, Yu-Wen ;

Ma, Bai-Ping .

PLANTA MEDICA, 2012, 78 (03) :276-285