Age effects on B cells and humoral immunity in humans

被引：189

作者：

Frasca, Daniela ^{[1
]}

Diaz, Alain ^{[1
]}

Romero, Maria ^{[1
]}

Landin, Ana Marie ^{[1
]}

Blomberg, Bonnie B. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Microbiol & Immunology, Miami, FL 33101 USA

来源：

AGEING RESEARCH REVIEWS | 2011年 / 10卷 / 03期

关键词：

Aging; B lymphocytes; Immunoglobulin class switch; Influenza vaccination; CLASS SWITCH RECOMBINATION; INDUCED CYTIDINE DEAMINASE; IG CLASS SWITCH; INFLUENZA VACCINATION; IMMUNOGLOBULIN ENHANCER; SOMATIC HYPERMUTATION; LYMPHOCYTE DEVELOPMENT; MESSENGER-RNA; T-CELLS; OLD-AGE;

D O I：

10.1016/j.arr.2010.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：330 / 335

页数：6

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