DNA-Based catalytic enantioselective Michael reactions in water

被引：179

作者：

Coquiere, David ^{[1
]}

Feringa, Ben L. ^{[1
]}

Roelfes, Gerard ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 48期

关键词：

asymmetric catalysis; copper; DNA; Michael addition;

D O I：

10.1002/anie.200703459

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High, but not dry: A highly enantioselective Michael reaction in water has been developed by using a simple DNA-based catalyst. Enantioselectivities of up to 99% ee could be obtained by using nitromethane and dimethyl malonate as the nucleophiles and αf,β-unsaturated 2-acylimidazoles as the Michael acceptors. The reactions can be performed on a preparative scale and the catalyst can be recycled. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9308 / 9311

页数：4

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[61] Coordinated design of cofactor and active site structures in development of new protein catalysts [J].