MR monitoring of focused ultrasound surgery in a breast tissue model in vivo

被引：37

作者：

Bohris, C

Jenne, JW

Rastert, R

Simiantonakis, I

Brix, G

Spoo, J

Hlavac, M

Nemeth, R

Huber, PE

Debus, J ^{[1
]}

机构：

[1] German Canc Res Ctr, DKFZ, Dept Radiooncol, D-6900 Heidelberg, Germany

[2] Siemens AG, D-8520 Erlangen, Germany

[3] Univ Heidelberg, Dept Radiat Oncol, Heidelberg, Germany

来源：

MAGNETIC RESONANCE IMAGING | 2001年 / 19卷 / 02期

关键词：

MRI guided therapy; focused ultrasound surgery; high intensity focused ultrasound; MRI thermometry; therapy monitoring;

D O I：

10.1016/S0730-725X(01)00229-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The objective of this study was to investigate MRI methods for monitoring focused ultrasound surgery (FUS) of breast tumors. To this end, the mammary glands of sheep were used as tissue model. The tissue was treated in vivo with numerous single sonications which covered extended target volumes by employing a scanning technique. The ultrasound focus position was controlled by online temperature mapping based on the temperature dependence of the relaxation time T-1. This approach proved to be reliable and offers thus an alternative to proton resonance frequency methods, whose application is hampered in fatty tissues. FUS-induced tissue changes were visible on T-2- as well as on pre- and post-contrast T-1-weighted images. According to our initial experience, noninvasive MRI-guided FUS of breast tumors is feasible. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：167 / 175

页数：9

共 28 条

[1] HIGH-INTENSITY FOCUSED ULTRASOUND FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA - EARLY UNITED-STATES CLINICAL-EXPERIENCE [J].