Using patient-specific hemodynamic response functions in combined EEG-fMRI studies in epilepsy

被引:61
作者
Kang, JK [1 ]
Bénar, CG [1 ]
Al-Asmi, A [1 ]
Khani, YA [1 ]
Pike, GB [1 ]
Dubeau, F [1 ]
Gotman, J [1 ]
机构
[1] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
基金
加拿大健康研究院;
关键词
simultaneous EEG-fMRI; hemodynamic response; subject-specific; BOLD; epilepsy; statistical analysis;
D O I
10.1016/S1053-8119(03)00290-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Combining electroencephalogram (EEG) and functional MRI (fMRI) allows localization of brain regions activated as a result of epileptic spikes. The statistical analysis of fMRI data usually includes a standard model of the hemodynamic response function (HRF) but it is not known how well this fits the actual HRF of epileptic spikes. The objective of this exploratory study was to compare the activated areas and t-statistical scores obtained with a standard HRF to those obtained with a patient-specific HRF. Eight patients with focal epilepsy were studied. We obtained an estimate of the patient-specific HRFs for each patient at the local maximum of activation in the standard HRF analysis. The activated areas obtained with the patient-specific HRFs were larger or similar to the originally activated areas. Additional activated areas were seen in five patients, and most were compatible with the EEG and anatomical MRI localization of epileptogenic and lesional regions. Using patient-specific HRFs brings increased sensitivity to the analysis of epileptic spikes by EEG-fMRI. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:1162 / 1170
页数:9
相关论文
共 31 条
[21]   Event-related fMRI with simultaneous and continuous EEG: Description of the method and initial case report [J].
Lemieux, L ;
Salek-Haddadi, A ;
Josephs, O ;
Allen, P ;
Toms, N ;
Scott, C ;
Krakow, K ;
Turner, R ;
Fish, DR .
NEUROIMAGE, 2001, 14 (03) :780-787
[22]   Characterizing the hemodynamic response: Effects of presentation rate, sampling procedure, and the possibility of ordering brain activity based on relative timing [J].
Miezin, FM ;
Maccotta, L ;
Ollinger, JM ;
Petersen, SE ;
Buckner, RL .
NEUROIMAGE, 2000, 11 (06) :735-759
[23]   INTRINSIC SIGNAL CHANGES ACCOMPANYING SENSORY STIMULATION - FUNCTIONAL BRAIN MAPPING WITH MAGNETIC-RESONANCE-IMAGING [J].
OGAWA, S ;
TANK, DW ;
MENON, R ;
ELLERMANN, JM ;
KIM, SG ;
MERKLE, H ;
UGURBIL, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :5951-5955
[24]   Event-related functional MRI: Past, present, and future [J].
Rosen, BR ;
Buckner, RL ;
Dale, AM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) :773-780
[25]   Presurgical evaluation of epilepsy [J].
Rosenow, F ;
Lüders, H .
BRAIN, 2001, 124 :1683-1700
[26]   Late onset of anterior prefrontal activity during true and false recognition: An event-related fMRI study [J].
Schacter, DL ;
Buckner, RL ;
Koutstaal, W ;
Dale, AM ;
Rosen, BR .
NEUROIMAGE, 1997, 6 (04) :259-269
[27]   Non-invasive epileptic focus localization using EEG-triggered functional MRI and electromagnetic tomography [J].
Seeck, M ;
Lazeyras, F ;
Michel, CM ;
Blanke, O ;
Gericke, CA ;
Ives, J ;
Delavelle, J ;
Golay, X ;
Haenggeli, CA ;
de Tribolet, N ;
Landis, T .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1998, 106 (06) :508-512
[28]   EEG-triggered echo-planar functional MRI in epilepsy [J].
Warach, S ;
Ives, JR ;
Schlaug, G ;
Patel, MR ;
Darby, DG ;
Thangaraj, V ;
Edelman, RR ;
Schomer, DL .
NEUROLOGY, 1996, 47 (01) :89-93
[29]   A general statistical analysis for fMRI data [J].
Worsley, KJ ;
Liao, CH ;
Aston, J ;
Petre, V ;
Duncan, GH ;
Morales, F ;
Evans, AC .
NEUROIMAGE, 2002, 15 (01) :1-15
[30]  
Worsley KJ, 1996, HUM BRAIN MAPP, V4, P58, DOI 10.1002/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO