Cross-coupling in flow

被引：322

作者：

Noel, Timothy ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 10期

关键词：

MICROWAVE-ASSISTED SYNTHESIS; CARBON BOND FORMATION; HYDROGEN SUBSTITUTION-REACTIONS; PALLADIUM-CATALYZED AMINATION; NICKEL-PHOSPHINE COMPLEXES; ORGANIC-SYNTHESIS MACOS; VISCOSITY IONIC LIQUID; MINI-CONTINUOUS FLOW; SUZUKI-MIYAURA; ARYL HALIDES;

D O I：

10.1039/c1cs15075h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Until recently, cross-coupling reactions have been exclusively performed in batch processes. With the advent of microfluidics, significant effort has been devoted to develop a wide variety of continuous-flow techniques to facilitate organic synthesis. In this critical review, we attempt to give an overview of the different continuous-flow methodologies that have been developed and utilized for cross-coupling reactions. In addition, we attempt to point out the advantages of continuous-flow when compared with their batch counterparts (246 references).

引用

页码：5010 / 5029

页数：20

共 246 条

[1] The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products by Using Continuous Flow Techniques [J].