The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products by Using Continuous Flow Techniques

被引：31

作者：

Achanta, Srinivas ^{[1
]}

Liautard, Virginie ^{[1
]}

Paugh, Robert ^{[1
]}

Organ, Michael G. ^{[1
]}

机构：

[1] York Univ, Dept Chem, Toronto, ON M3J 1P3, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 43期

基金：

加拿大自然科学与工程研究理事会;

关键词：

flow chemistry; Heck reaction; microwave chemistry; tyramine; ORGANIC-SYNTHESIS MACOS; THIN-FILMS; CAPILLARIES; INHIBITOR; AMIDES; GOLD;

D O I：

10.1002/chem.201002102

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A flowing future! A multistep, general flow chemistry protocol has been developed for the preparation of tyramine-based natural products. The process integrates room-temperature reactions with high-temperature Heck coupling reactions, where the heat has been supplied by microwave irradiation. As a proof of concept for 'scaling out' to attain larger quantities of the desired products, the four primary tyramine-based natural products were prepared on a gram scale using this synthetic protocol. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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收藏

页码：12797 / 12800

页数：4

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