Directional Coronary atherectomy for the treatment of Palmaz-Schatz in-stent restenosis

被引:56
作者
Mahdi, NA [1 ]
Pathan, AZ [1 ]
Harrell, L [1 ]
Leon, MN [1 ]
Lopez, J [1 ]
Butte, A [1 ]
Ferrell, M [1 ]
Gold, HK [1 ]
Palacios, IF [1 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Med,Cardiac Unit,Cardiac Catheterizat Lab, Boston, MA 02114 USA
关键词
D O I
10.1016/S0002-9149(98)00639-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Management of in-stent restenosis has become a significant challenge in interventional cardiology. The results of balloon angioplasty have been disappointing due to the high recurrence of restenosis at follow-vp. Debulking of the restenotic tissue within the stents using directional coronary atherectomy (DCA) may offer a therapeutic advantage. We report the immediate clinical and angiographic outcomes and long-term clinical follow-up results of 45 patients (46 lesions), mean age 63 +/- 12 years, 73% men, with ct mean reference diameter of 2.9 +/- 0.6 mm, treated with DCA for symptomatic Palmaz-Schatz in-stent restenosis. DCA was performed successfully in all 46 lesions and resulted In a postprocedural minimal luminal diameter of 2.7 +/- 0.7 mm and a residual diameter stenosis of 17 +/- 10%. There were no in-hospital deaths, Q-wave myocardial infarctions, or emergency coronary artery bypass surgeries. Four patients (9%) suffered a non-Q-wave myocardial infarction. Target lesion revascularization was 28.3% at a mean follow-vp of 10 +/- 4.6 months. Kaplan-Meier event-free survival (freedom from death, myocardial infarction, and repeat target lesion revascularization) was 71.2% and 64.7% at 6 and 12 months after DCA, respectively. Thus, DCA is safe and efficacious for the treatment of Palmaz-Schatz in-stent restenosis. It results in a large postprocedural minimal luminal diameter and a low rate of both target lesion revascularization and combined major clinical evens at follow-vp. (C) 1998 by Excerpta Medica, Inc.
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页码:1345 / 1351
页数:7
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