Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

被引：28

作者：

Memish, Ziad A. ^{[1
,2
]}

Alsahly, Ahmad ^{[3
]}

al Masri, Malak ^{[1
]}

Heil, Gary L. ^{[4
]}

Anderson, Benjamin D. ^{[4
]}

Peiris, Malik ^{[5
,6
]}

Khan, Salah Uddin ^{[4
,7
]}

Gray, Gregory C. ^{[4
]}

机构：

[1] Minist Hlth, Riyadh, Saudi Arabia

[2] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia

[3] Reg Hlth Directorate, Jazan, Saudi Arabia

[4] Univ Florida, Emerging Pathogens Inst, Coll Publ Hlth & Hlth Profess, Gainesville, FL USA

[5] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China

[6] Univ Hong Kong, HKU Pasteur Res Pole, Hong Kong, Hong Kong, Peoples R China

[7] ICDDR B, Ctr Communicable Dis, Dhaka, Bangladesh

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2015年 / 9卷 / 02期

关键词：

antibody; Kingdom of Saudi Arabia; MERS-CoV; pseudoparticle virus neutralization assays; DROMEDARY CAMELS; CORONAVIRUS; ANTIBODIES;

D O I：

10.1111/irv.12287

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay.None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.

引用

页码：64 / 67

页数：4

共 12 条

[1] Investigation of Anti-Middle East Respiratory Syndrome Antibodies in Blood Donors and Slaughterhouse Workers in Jeddah and Makkah, Saudi Arabia, Fall 2012
Aburizaiza, Asad S.
Mattes, Frank M.
Azhar, Esam I.
Hassan, Ahmed M.
Memish, Ziad A.
Muth, Doreen
Meyer, Benjamin
Lattwein, Erik
Mueller, Marcel A.
Drosten, Christian
[J]. JOURNAL OF INFECTIOUS DISEASES, 2014, 209 (02) : 243 - 246
[2] Hospital-Associated Outbreak of Middle East Respiratory Syndrome Coronavirus: A Serologic, Epidemiologic, and Clinical Description
Al-Abdallat, Mohammad Mousa
Payne, Daniel C.
Alqasrawi, Sultan
Rha, Brian
Tohme, Rania A.
Abedi, Glen R.
Al Nsour, Mohannad
Iblan, Ibrahim
Jarour, Najwa
Farag, Noha H.
Haddadin, Aktham
Al-Sanouri, Tarek
Tamin, Azaibi
Harcourt, Jennifer L.
Kuhar, David T.
Swerdlow, David L.
Erdman, Dean D.
Pallansch, Mark A.
Haynes, Lia M.
Gerber, Susan I.
[J]. CLINICAL INFECTIOUS DISEASES, 2014, 59 (09) : 1225 - 1233
[3] CDC, 2014, MERS CLIN FEAT MIDDL
[4] MERS Coronaviruses in Dromedary Camels, Egypt
Chu, Daniel K. W.
Poon, Leo L. M.
Gomaa, Mokhtar M.
Shehata, Mahmoud M.
Perera, Ranawaka A. P. M.
Abu Zeid, Dina
El Rifay, Amira S.
Siu, Lewis Y.
Guan, Yi
Webby, Richard J.
Ali, Mohamed A.
Peiris, Malik
Kayali, Ghazi
[J]. EMERGING INFECTIOUS DISEASES, 2014, 20 (06) : 1049 - 1053
[5] Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity
Hemida, M. G.
Perera, R. A.
Al Jassim, R. A.
Kayali, G.
Siu, L. Y.
Wang, P.
Chu, K. W.
Perlman, S.
Ali, M. A.
Alnaeem, A.
Guan, Y.
Poon, L. L.
Saif, L.
Peiris, M.
[J]. EUROSURVEILLANCE, 2014, 19 (23): : 2 - 7
[6] Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, Oman, 2013
Nowotny, N.
Kolodziejek, J.
[J]. EUROSURVEILLANCE, 2014, 19 (16) : 11 - 15
[7] Organization WHO, 2003, WHO ISS GLOB AL CAS
[8] Perera RA, 2013, EUROSURVEILLANCE, V18, P8, DOI 10.2807/1560-7917.ES2013.18.36.20574
[9] Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
Reusken, Chantal B. E. M.
Haagmans, Bart L.
Mueller, Marcel A.
Gutierrez, Carlos
Godeke, Gert-Jan
Meyer, Benjamin
Muth, Doreen
Raj, V. Stalin
Smits-De Vries, Laura
Corman, Victor M.
Drexler, Jan-Felix
Smits, Saskia L.
El Tahir, Yasmin E.
De Sousa, Rita
van Beek, Janko
Nowotny, Norbert
van Maanen, Kees
Hidalgo-Hermoso, Ezequiel
Bosch, Berend-Jan
Rottier, Peter
Osterhaus, Albert
Gortazar, Christian
Drosten, Christian
Koopmans, Marion P. G.
[J]. LANCET INFECTIOUS DISEASES, 2013, 13 (10) : 859 - 866
[10] WHO, 2014, MIDDL E RESP SYNDR C

← 1 2 →