Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside

被引：18

作者：

Özkan, A ^{[1
]}

Apak, H ^{[1
]}

Celkan, T ^{[1
]}

Yüksel, L ^{[1
]}

Yildiz, I ^{[1
]}

机构：

[1] Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat Hematol Oncol, Istanbul, Turkey

来源：

PEDIATRIC DERMATOLOGY | 2001年 / 18卷 / 01期

关键词：

D O I：

10.1046/j.1525-1470.2001.018001038.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C), A 13-year-old girl with acute lymphocytic leukemia was treated according to the protocol of the BFM Group (BFM-95, HRG), On the fifth day after administration of a high dose of ARA-C (2 g/m(2) intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day, ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.

引用

页码：38 / 40

页数：3

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