Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes

被引：99

作者：

Chon, Hyangah ^{[1
]}

Lee, Sangyeop ^{[1
]}

Yoon, Soo-Young

Chang, Soo-Ik ^{[2
,3
]}

Lim, Dong Woo ^{[1
]}

Choo, Jaebum ^{[1
]}

机构：

[1] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea

[2] Korea Univ, Coll Med, Dept Lab Med, Ansan 425707, South Korea

[3] Chungbuk Natl Univ, Dept Biochem, Cheongju 361763, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 46期

基金：

新加坡国家研究基金会;

关键词：

ENHANCED RAMAN-SCATTERING; GOLD NANOSPHERES; NANOPARTICLES; MICROARRAY; PROTEINS; ANTIBODY; LABELS; BEADS; CHIP;

D O I：

10.1039/c1cc15707h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A quick and reproducible SERS-based immunoassay, using functionalized hollow gold nanospheres and magnetic beads, has been developed. Here, a simultaneous detection of dual cancer markers in blood serum has been achieved under a single excitation wavelength. The accuracy and sensitivity for clinical sera from five patients confirms their diagnostic feasibility.

引用

页码：12515 / 12517

页数：3

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