Three-dimensional characterization of optical coherence tomography point spread functions with a nanoparticle-embedded phantom

被引：53

作者：

Agrawal, Anant ^{[1
]}

Pfefer, T. Joshua ^{[1
]}

Gilani, Naureen ^{[1
]}

Drezek, Rebekah ^{[2
]}

机构：

[1] US FDA, Opt Diagnost Devices Lab, Ctr Devices & Radiol Hlth, Silver Spring, MD 20993 USA

[2] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

来源：

OPTICS LETTERS | 2010年 / 35卷 / 13期

关键词：

MICROSCOPY; RESOLUTION;

D O I：

10.1364/OL.35.002269

中图分类号：

O43 [光学];

学科分类号：

070207 [光学];

摘要：

We present a novel (to our knowledge) approach for measurement of the three-dimensional point spread function (PSF) of optical coherence tomography (OCT) systems using a nanoparticle-embedded phantom (NEP), toward development of standardized test methods for biophotonic imaging. The NEP comprises highly reflective plasmonic nanoparticles, homogeneously distributed in a transparent silicone matrix. OCT image volumes were analyzed to characterize PSFs in axial and lateral directions at a variety of locations in the NEP. Results indicate submicrometer agreement with conventional approaches to measure dimensions of the PSF. The NEP offers a robust approach for validating and comparing imaging performance of OCT devices. (C) 2010 Optical Society of America

引用

页码：2269 / 2271

页数：3

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