Entropy loss in long-distance DNA looping

被引：34

作者：

Hanke, A

Metzler, R

机构：

[1] Univ Stuttgart, Inst Theoret Phys, D-7000 Stuttgart, Germany

[2] Univ Oxford, Dept Phys Theoret Phys, Oxford, England

[3] NORDITA Nordic Inst Theoret Phys, Copenhagen, Denmark

[4] MIT, Dept Phys, Cambridge, MA 02139 USA

来源：

BIOPHYSICAL JOURNAL | 2003年 / 85卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0006-3495(03)74463-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The entropy loss due to the formation of one or multiple loops in circular and linear DNA chains is calculated from a scaling approach in the limit of long chain segments. The analytical results allow us to obtain a fast estimate for the entropy loss for a given configuration. Numerical values obtained for some examples suggest that the entropy loss encountered in loop closure in typical genetic switches may become a relevant factor in comparison to both k(B)T and typical bond energies in biopolymers, which has to be overcome by the released bond energy between the looping contact sites.

引用

页码：167 / 173

页数：7

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