Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat

被引：31

作者：

Kovács, P ^{[1
]}

Klöting, I ^{[1
]}

机构：

[1] Univ Greifswald, Inst Pathophysiol, Dept Lab Anim Sci, D-17495 Karlsburg, Germany

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1998年 / 354卷 / 01期

关键词：

lipids; rat; chromosome; quantitative trait locus;

D O I：

10.1006/abbi.1998.0686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The spontaneously hypertensive rat (SHR/Mol) and the spontaneously diabetic BB/OK rat were crossed, and the F1 hybrids were backcrossed onto the BB/OK rat in order to search for quantitative trait loci (QTL) affecting serum total cholesterol and triglycerides on chromosomes 1, 3, 4, 10, 13, 18, and X. On chromosome 4 a QTL for triglyceride levels (lod score 3.3) was found within the region flanked by the D4Mit9 and Il-6 markers. Suggestive linkage (lod score 1.9) was found for total cholesterol on chromosome 4 at the Spr locus. Also, on chromosome 1 suggestive linkage for both investigated traits was found at marker D1Mit14 (lod score 1.9 for triglycerides, 2.1 for total cholesterol). The results of the study could contribute to the explanation of the genetic basis of lipid abnormalities, which are a common feature of pathological disorders such as coronary heart disease, hypertension, or noninsulin-dependent diabetes. (C) 1998 Academic Press.

引用

页码：139 / 143

页数：5

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