Development of novel diagnostic and prognostic molecular markers for sporadic colon cancer

被引：11

作者：

Ahmed, FE ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Radiat Oncol, Leo W Jenkins Canc Ctr, Greenville, NC 27858 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2005年 / 5卷 / 03期

关键词：

differential display; diagnosis; markers; microarrays; prognosis; RT-PCR; SAGE; screening; SSH;

D O I：

10.1586/14737159.5.3.337

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gene expression studies are informative about changes in colon cancer, increase understanding of the biology of tumorigenesis and aid in developing diagnostic and prognostic markers. In this review, expression techniques used to examine the multistage process of colon cancer are discussed. Many genes have been found to differ in expression between normal and fumorigenic states, as early as the seemingly normal colonic crypts. The clinical usefulness of markers varies with stage, ethnicity and anatomic location of colon cancer. Thus, combinations of markers can be used to develop an approach to molecularly screen and follow the progression of this prevalent cancer.

引用

页码：337 / 352

页数：16

共 94 条

[41] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

[42]

Hitt E, 2004, SCIENTIST, V18, P38

[43] PCR technology for screening and quantification of genetically modified organisms (GMOs) [J].

Holst-Jensen, A ;

Ronning, SB ;

Lovseth, A ;

Berdal, KG .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 375 (08) :985-993

[44] A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization [J].

Hufton, SE ;

Moerkerk, PT ;

Brandwijk, R ;

de Bruïne, AP ;

Arends, JW ;

Hoogenboom, HR .

FEBS LETTERS, 1999, 463 (1-2) :77-82

[45] Aberrant DNA methylation: Have we entered the era of more than one type of colorectal cancer? [J].

Iacopetta, B .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (04) :1043-1045

[46] Prospective blinded evaluation of computed tomographic colonography for screen detection of colorectal polyps [J].

Johnson, CD ;

Harmsen, WS ;

Wilson, LA ;

MacCarty, RL ;

Welch, TJ ;

Ilstrup, DM ;

Ahlquist, DA .

GASTROENTEROLOGY, 2003, 125 (02) :311-319

[47]

Kitahara O, 2001, CANCER RES, V61, P3544

[48]

Koketsu S, 2004, HEPATO-GASTROENTEROL, V51, P638

[49]

Kusnezow W., 2002, BIOTECHNIQUES, V33, pS14

[50] Gene expression pattern of laser microdissected colonic crypts of adenomas with low grade dysplasia [J].

Lechner, S ;

Müller-Ladner, U ;

Renke, B ;

Schölmerich, J ;

Rüschoff, J ;

Kullmann, F .

GUT, 2003, 52 (08) :1148-1153

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