Development of novel diagnostic and prognostic molecular markers for sporadic colon cancer

被引：11

作者：

Ahmed, FE ^{[1
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Dept Radiat Oncol, Leo W Jenkins Canc Ctr, Greenville, NC 27858 USA

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2005年 / 5卷 / 03期

关键词：

differential display; diagnosis; markers; microarrays; prognosis; RT-PCR; SAGE; screening; SSH;

D O I：

10.1586/14737159.5.3.337

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gene expression studies are informative about changes in colon cancer, increase understanding of the biology of tumorigenesis and aid in developing diagnostic and prognostic markers. In this review, expression techniques used to examine the multistage process of colon cancer are discussed. Many genes have been found to differ in expression between normal and fumorigenic states, as early as the seemingly normal colonic crypts. The clinical usefulness of markers varies with stage, ethnicity and anatomic location of colon cancer. Thus, combinations of markers can be used to develop an approach to molecularly screen and follow the progression of this prevalent cancer.

引用

页码：337 / 352

页数：16

共 94 条

[71] A statistical perspective on gene expression data analysis [J].

Satagopan, JM ;

Panageas, KS .

STATISTICS IN MEDICINE, 2003, 22 (03) :481-499

[72] American Cancer Society guidelines for the early detection of cancer: Update of early detection guidelines for prostate, colorectal, and endometrial cancers - ALSO: Update 2001 - Testing for early lung cancer detection [J].

Smith, RA ;

von Eschenbach, AC ;

Wender, R ;

Levin, B ;

Byers, T ;

Rothenberger, D ;

Brooks, D ;

Creasman, W ;

Cohen, C ;

Runowicz, C ;

Saslow, D ;

Cokkinides, V ;

Eyre, H .

CA-A CANCER JOURNAL FOR CLINICIANS, 2001, 51 (01) :38-75

[73]

Srivastava S, 2001, CLIN CANCER RES, V7, P1118

[74] DNA microarrays: a new diagnostic tool and its implications in colorectal cancer [J].

Stremmel, C ;

Wein, A ;

Hohenberger, W ;

Reingruber, B .

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2002, 17 (03) :131-136

[75] Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype [J].

Toyota, M ;

Ohe-Toyota, M ;

Ahuja, N ;

Issa, JPJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :710-715

[76] CpG island methylator phenotype in colorectal cancer [J].

Toyota, M ;

Ahuja, N ;

Ohe-Toyota, M ;

Herman, JG ;

Baylin, SB ;

Issa, JPJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8681-8686

[77] Differential display probes for cDNA arrays [J].

Trenkle, T ;

Welsh, J ;

McClelland, M .

BIOTECHNIQUES, 1999, 27 (03) :554-+

[78] Detection and clinical significance of occult tumour cells in colorectal cancer [J].

Tsavellas, G ;

Patel, H ;

Allen-Mersh, TG .

BRITISH JOURNAL OF SURGERY, 2001, 88 (10) :1307-1320

[79] SERIAL ANALYSIS OF GENE-EXPRESSION [J].

VELCULESCU, VE ;

ZHANG, L ;

VOGELSTEIN, B ;

KINZLER, KW .

SCIENCE, 1995, 270 (5235) :484-487

[80] A high throughput screening for rarely transcribed differentially expressed genes [J].

vonStein, OD ;

Thies, WG ;

Hofmann, M .

NUCLEIC ACIDS RESEARCH, 1997, 25 (13) :2598-2602

← 1 2 3 4 5 6 7 8 9 10 →