The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics

被引：189

作者：

Blake, Judith A. ^{[1
]}

Bult, Carol J. ^{[1
]}

Kadin, James A. ^{[1
]}

Richardson, Joel E. ^{[1
]}

Eppig, Janan T. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

基金：

美国国家卫生研究院;

关键词：

BIOLOGY;

D O I：

10.1093/nar/gkq1008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mouse Genome Database (MGD) is the community model organism database for the laboratory mouse and the authoritative source for phenotype and functional annotations of mouse genes. MGD includes a complete catalog of mouse genes and genome features with integrated access to genetic, genomic and phenotypic information, all serving to further the use of the mouse as a model system for studying human biology and disease. MGD is a major component of the Mouse Genome Informatics (MGI, http://www.informatics.jax.org/) resource. MGD contains standardized descriptions of mouse phenotypes, associations between mouse models and human genetic diseases, extensive integration of DNA and protein sequence data, normalized representation of genome and genome variant information. Data are obtained and integrated via manual curation of the biomedical literature, direct contributions from individual investigators and downloads from major informatics resource centers. MGD collaborates with the bioinformatics community on the development and use of biomedical ontologies such as the Gene Ontology (GO) and the Mammalian Phenotype (MP) Ontology. Major improvements to the Mouse Genome Database include comprehensive update of genetic maps, implementation of new classification terms for genome features, development of a recombinase (cre) portal and inclusion of all alleles generated by the International Knockout Mouse Consortium (IKMC).

引用

页码：D842 / D848

页数：7

共 21 条

[1] McKusick's Online Mendelian Inheritance in Man (OMIM®) [J].

Amberger, Joanna ;

Bocchini, Carol A. ;

Scott, Alan F. ;

Hamosh, Ada .

NUCLEIC ACIDS RESEARCH, 2009, 37 :D793-D796

[2] The Gene Ontology in 2010: extensions and refinements The Gene Ontology Consortium [J].

Berardini, Tanya Z. ;

Li, Donghui ;

Huala, Eva ;

Bridges, Susan ;

Burgess, Shane ;

McCarthy, Fiona ;

Carbon, Seth ;

Lewis, Suzanna E. ;

Mungall, Christopher J. ;

Abdulla, Amina ;

Wood, Valerie ;

Feltrin, Erika ;

Valle, Giorgio ;

Chisholm, Rex L. ;

Fey, Petra ;

Gaudet, Pascale ;

Kibbe, Warren ;

Basu, Siddhartha ;

Bushmanova, Yulia ;

Eilbeck, Karen ;

Siegele, Deborah A. ;

McIntosh, Brenley ;

Renfro, Daniel ;

Zweifel, Adrienne ;

Hu, James C. ;

Ashburner, Michael ;

Tweedie, Susan ;

Alam-Faruque, Yasmin ;

Apweiler, Rolf ;

Auchinchloss, Andrea ;

Bairoch, Amos ;

Barrell, Daniel ;

Binns, David ;

Blatter, Marie-Claude ;

Bougueleret, Lydie ;

Boutet, Emmanuel ;

Breuza, Lionel ;

Bridge, Alan ;

Browne, Paul ;

Chan, Wei Mun ;

Coudert, Elizabeth ;

Daugherty, Louise ;

Dimmer, Emily ;

Eberhardt, Ruth ;

Estreicher, Anne ;

Famiglietti, Livia ;

Ferro-Rojas, Serenella ;

Feuermann, Marc ;

Foulger, Rebecca ;

Gruaz-Gumowski, Nadine .

NUCLEIC ACIDS RESEARCH, 2010, 38 :D331-D335

[3] The Mouse Genome Database genotypes::phenotypes [J].

Blake, Judith A. ;

Bult, Carol J. ;

Eppig, Janan T. ;

Kadin, James A. ;

Richardson, Joel E. .

NUCLEIC ACIDS RESEARCH, 2009, 37 :D712-D719

[4] The Mouse Genome Database (MGD): mouse biology and model systems [J].

Bult, Carol J. ;

Eppig, Janan T. ;

Kadin, James A. ;

Richardson, Joel E. ;

Blake, Judith A. .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D724-D728

[5] The Mouse Genome Database: enhancements and updates [J].

Bult, Carol J. ;

Kadin, James A. ;

Richardson, Joel E. ;

Blake, Judith A. ;

Eppig, Janan T. .

NUCLEIC ACIDS RESEARCH, 2010, 38 :D586-D592

[6] A new partner for The International Knockout Mouse Consortium [J].

Collins, Francis S. ;

Finnell, Richard H. ;

Rossant, Janet ;

Wurst, Wolfgang .

CELL, 2007, 129 (02) :235-235

[7] A mouse for all reasons [J].

Collins, Francis S. .

CELL, 2007, 128 (01) :9-13

[8] A New Standard Genetic Map for the Laboratory Mouse [J].

Cox, Allison ;

Ackert-Bicknell, Cheryl L. ;

Dumont, Beth L. ;

Ding, Yueming ;

Bell, Jordana Tzenova ;

Brockmann, Gudrun A. ;

Wergedal, Jon E. ;

Bult, Carol ;

Paigen, Beverly ;

Flint, Jonathan ;

Tsaih, Shirng-Wern ;

Churchill, Gary A. ;

Broman, Karl W. .

GENETICS, 2009, 182 (04) :1335-1344

[9] The Rat Genome Database 2009: variation, ontologies and pathways [J].

Dwinell, Melinda R. ;

Worthey, Elizabeth A. ;

Shimoyama, Mary ;

Bakir-Gungor, Burcu ;

DePons, Jeffrey ;

Laulederkind, Stanley ;

Lowry, Timothy ;

Nigram, Rajni ;

Petri, Victoria ;

Smith, Jennifer ;

Stoddard, Alexander ;

Twigger, Simon N. ;

Jacob, Howard J. .

NUCLEIC ACIDS RESEARCH, 2009, 37 :D744-D749

[10] The Sequence Ontology: a tool for the unification of genome annotations [J].

Eilbeck, K ;

Lewis, SE ;

Mungall, CJ ;

Yandell, M ;

Stein, L ;

Durbin, R ;

Ashburner, M .

GENOME BIOLOGY, 2005, 6 (05)

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