Bismuth triflate-chiral bipyridine complexes as water-compatible chiral Lewis acids

被引：125

作者：

Kobayashi, S ^{[1
]}

Ogino, T ^{[1
]}

Shimizu, H ^{[1
]}

Ishikawa, S ^{[1
]}

Hamada, T ^{[1
]}

Manabe, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, HFRE Div, ERATO,Japan Sci & Technol Agcy,Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 21期

关键词：

D O I：

10.1021/ol051965w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic asymmetric hydroxymethylation of silicon enolates with an aqueous formaldehyde solution has been developed using a chiral bismuth complex. This is the first example of highly enantioselective reactions using a chiral bismuth catalyst in aqueous media. In this paper, we have added Bi(OTf)(3)-1 complex as a "water-compatible Lewis acid". Bi(OTf)(3) is unstable in the presence of water but is stabilized by the basic ligand.

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页码：4729 / 4731

页数：3

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