Biocatalysis for the preparation of optically active beta-lactam precursors of amino acids

被引：65

作者：

Csomos, P

Kanerva, LT

Bernath, G

Fulop, F

机构：

[1] UNIV TURKU,DEPT CHEM,FIN-20014 TURKU,FINLAND

[2] UNIV TURKU,DEPT BIOMED,FIN-20014 TURKU,FINLAND

[3] ALBERT SZENT GYORGYI MED UNIV,INST PHARMACEUT CHEM,H-6701 SZEGED,HUNGARY

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 06期

关键词：

D O I：

10.1016/0957-4166(96)00214-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantioselective acylation of N-hydroxymethylated beta-lactams in the presence of Pseudomonas sp. lipase afforded optically active precursors for the preparation of (1R,2S)- and (1S,2R)-2-aminocyclopentane- and (1R,2S,3R,4S)- and (1S,2R,3S,4R)-3-aminobicyclo[2.2.1]heptanecarboxylic acids. Due to the high enantioselectivity (E = 90 and 62) and in order to minimize the enzymatic hydrolysis of the acylated products back to the starting alcohol, the reactions were performed in acetone. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1789 / 1796

页数：8

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