Plasma Bilirubin and UGT1A1*28 Are Not Protective Factors Against First-Time Myocardial Infarction in a Prospective, Nested Case-Referent Setting

被引：31

作者：

Ekblom, Kim ^{[1
]}

Marklund, Stefan L. ^{[1
]}

Jansson, Jan-Hakan ^{[3
]}

Osterman, Pia ^{[1
]}

Hallmans, Goran ^{[2
]}

Weinehall, Lars ^{[2
]}

Hultdin, Johan ^{[1
]}

机构：

[1] Umea Univ, Dept Med Biosci, SE-90185 Umea, Sweden

[2] Umea Univ, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden

[3] Skelleftea Cty Hosp, Skelleftea, Sweden

来源：

CIRCULATION-CARDIOVASCULAR GENETICS | 2010年 / 3卷 / 04期

关键词：

bilirubin; myocardial infarction; risk factors; epidemiology; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; LOW SERUM BILIRUBIN; HEART-DISEASE; CARDIOVASCULAR-DISEASE; APOLIPOPROTEIN-B; HEME OXYGENASE-1; INCREASED RISK; MAJOR GENE; UGT1A1;

D O I：

10.1161/CIRCGENETICS.109.861773

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-Bilirubin, an effective antioxidant, shows a large variation in levels between individuals and has been positively associated with reduced cardiovascular disease risk. A major reason for the variability is a common promoter polymorphism, UGT1A1*28, which reduces the transcription of the enzyme that conjugates bilirubin, UDP-glucuronosyltransferase 1A1. The aim of the study was to evaluate a possible protective effect of plasma bilirubin and the UGT1A1*28 polymorphism against myocardial infarction in a prospective case-referent setting. Methods and Results-Subjects (n=618) with a first-ever myocardial infarction (median event age, 60.5 years; median lag time, 3.5 years) and 1184 matched referents were studied. Plasma bilirubin was lower in cases versus referents. Despite a strong gene-dosage effect on bilirubin levels in both cases and referents, the UGT1A1*28 polymorphism did not influence the risk of myocardial infarction. Among multiple other variables, serum iron showed one of the strongest associations with bilirubin levels. Conclusions-We found no evidence for a protective effect of the UGT1A1*28 polymorphism against myocardial infarction and consequently neither for bilirubin. The lower bilirubin levels in cases might be caused by decreased production, increased degradation, or increased elimination. (Circ Cardiovasc Genet. 2010;3:340-347.)

引用

页码：340 / U100

页数：10

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